Patients intolerant to ACEs were not eligible for the ONTARGET(R) study. Intolerance to ACE was a requirement for enrolment into TRANSCEND(R).
The sponsor of the ONTARGET(R) Trial Programme is Boehringer Ingelheim; co-funders in selected countries are Bayer HealthCare and GlaxoSmithKline.
Boehringer Ingelheim
The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 135 affiliates in 47 countries and 39,800 employees. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel products of high therapeutic value for human and veterinary medicine.
In 2007, Boehringer Ingelheim posted net sales of 10.9 billion euro while spending one fifth of net sales in its largest business segment Prescription Medicines on research and development.
For more information please visit http://www.boehringer-ingelheim.com
References
(x) -1.6 mmHg, 95% CI from -2.5 to -0.6 mmHg (p=0.0012)) and -2.7 mmHg, 95% CI from -4.2 to -1.2 mmHg (p=0.0003) respectively
(1) Trials.Boehringer-Ingelheim.com. Boehringer Ingelheim Trial Number 502.480
(2) Trials.Boehringer-Ingelheim.com. Boehringer Ingelheim Trial Number 502.491
(3) White WB, Murwin D, Chrysant SG, Koval SE, Davidai G, Guthrie R. Blood Press Monit. 2008 Feb;13(1):21-27
(4) The ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Eng J Med. Published online 31 Mar 2008
(5) Bakris G, et al. Influence of glycemic control on proteinuria in patients with type 2 diabetes and overt nephropathy and hypertension: results of the AMADEO trial. 67th Sci Sess of the American Diabetes Association (ADA), Chicago, 22 - 26 Jun 2007 (Poster) 2007.
(6) Williams B, et al. The prospective, randomised investigation of the safety and efficacy of telmisartan versus ramipril using ambulatory blood pressure monitoring (PRISMAI). J Hypertens 2006; 24:193-200.
(7) Lacourciere Y, et al. A multicenter, 14-weeks study of telmisartan and ramipril in patients with mild to moderate hypertension using ambulatory blood pressure monitoring. Am J Hypertens 2006; 19:104-12
(8) The ONTARGET/TRANSCEND Investigators. Rationale, design, and baseline characteristics of 2 large , simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (ONTARGET/TRANSCEND) trials Am Heart J 2004; 148(1):52-61.
Contact: Dr. Reinhard Malin, CD Communications, Boehringer Ingelheim GmbH, 55216 Ingelheim am Rhein, GERMANY, Phone: +49-6132-77-90815, Fax: +49-6132-77-66-01, E-mail: press@boehringer-ingelheim.com
