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[1] JIA ACR30 response is defined as 3 of the 6 core components improving (from the Baseline assessments) by greater than or equal to 30%, with no more than 1 of the remaining components worsening by > 30%. Core components include Physician global assessment of disease activity VAS; Parent/patient global assessment of overall well-being VAS; Number of joints with active arthritis; Number of joints with limitation of movement; Erythrocyte Sedimentation Rate (ESR); Functional ability - Childhood Health Assessment Questionnaire (CHAQ)
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[1] Efficacy and safety of tocilizumab in patients with systemic Juvenile Idiopathic Arthritis (sJIA): 12-week data from the phase 3 tender trial. Abstract presented on 18th June 2010 at EULAR
[2] Woo, P. Systemic juvenile rheumatoid arthritis: diagnosis, management, and outcome. Nature Clinical Practice: Rheumatology. 2006. 2:1
[3] Symmons DP et al. Pediatric rheumatology in the United Kingdom: data from the British Paediatric Rheumatology Group National Diagnostic Register. J Rheumatology 1996: 23: 1975-1980
[4] Fishman D et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998: 102: 1369-1376
[5] Lomater C, Gerloni V, Gattinara M, Mazotti J, Cimaz R, Fantini F. et al. Systemic onset juvenile idiopathic arthritis: a retrospective study of 80 consecutive patients followed for 10 years. J Rheumatol. 2000;27:491- 96.
[6] Prieur AM, Bremard-Oury C, Griscelli C, Mozziconacci P. Prognosis of the systemic forms of juvenile chronic arthritis. Apropos of 100 cases. Arch Fr Pediatr. 1984;41:91-7.
[7] Cassidy JT, et al. Juvenile rheumatoid arthritis. Cassidy JT, Petty RE, eds. Textbook of pediatric rheumatology 2001:218-322
[8] Yokota, S. et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. The Lancet 2008; 371: 998-1006
[9] Yokota, S. et al. Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis & Rheumatism 2005; 52: 818-825
[10] Benedetti F. Inflammatory cytokines in the pathogenesis and treatment of systemic juvenile idiopathic arthritis. Pediatric Rheumatology Online Journal. 2005. Vol 3: 2
[11] Long-term efficacy of tocilizumab in rheumatoid arthritis for up to 3.5 years. Smolen J et al. Oral presentation at ACR, 18th October 2009
[12] LITHE: Tocilizumab inhibits radiographic progression and improves physical function in rheumatoid arthritis (RA) patients (Pts) at 2 years with increasing clinical efficacy over time. Fleischmann, R et al. Oral presentation at ACR, 18th October 2009
[13] Jones G et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis. 2010: 69: 88-96. Originally published online March 17, 2009. doi: 10.1136/ard.2008.105197
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