Actualizado 26/03/2012 22:27
- Comunicado -

Sanofi and Regeneron Report Phase 2 Data for Potential First-in-Class Lipid-Lowering PCSK9 Antibody (y 3)

        
        (1) McKenney JM, et al. A randomized, double-blind, placebo-controlled trial of the
        safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin
        type 9 serine protease, REGN727/SAR236553, in patients with primary
        hypercholesterolemia. Presented at the 61st ACC Annual Meeting, Chicago, IL, USA; March
        26, 2012. Abstract No. #306-10.
        (2) Roth E, et al. The effects of co-administering a monoclonal antibody to proprotein
        convertase subtilisin/kexin 9, REGN727/SAR236553, with 10 and 80 mg atorvastatin
        compared to 80 mg alone in patients with primary hypercholesterolemia. Presented at the
        61st ACC Annual Meeting, Chicago, IL, USA; March 26, 2012. Abstract No. #911-5.
        (3) Seidah NG, et al. The secretory proprotein convertase neural apoptosis-regulated
        convertase 1 (NARC-1): Liver regeneration and neuronal differentiation. PNAS 2003;100
        :928-33.
        (4) Park SW, et al. Post-transcriptional regulation of low density lipoprotein receptor
        protein by proprotein convertase subtilisin/kexin Type 9a in mouse liver. J Biol Chem
        2004;279:50630-8.
        (5) Cohen JC et al. Sequence variations in PCSK9, low LDL, and protection against
        coronary heart disease. N Engl J Med 2006;354:1264-72.
        (6) Long-Term Safety and Tolerability of SAR236553 (REGN727) in High Cardiovascular
        Risk Patients With Hypercholesterolemia. Available at:
        http://www.clinicaltrials.gov/ct2/show/N.... Last accessed 9 Feb 2012.
        (7) Farnier M. The role of proprotein convertase subtilisin/kexin type 9 in
        hyperlipidemia: focus on therapeutic implications. Am J Cardiovasc Drugs
        2011;11:145-52.

CONTACT: Sanofi: Media Relations: Marisol Peron, Tel:+33-(0)-1-53-77-45-02, Mobile: +33-(0)-6-08-18-94-78,marisol.peron@sanofi.com; Investor Relations: Sebastien Martel,+33-(0)1-53-77-45-45, IR@sanofi.com; or Regeneron: Media Relations: PeterDworkin, +1-914-847-7640, peter.dworkin@regeneron.com; Investor Relations:Michael Aberman, M.D., +1-914-847-7799, michael.aberman@regeneron.com

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