In the ongoing Phase I study, AZD9291 has shown early evidence of activity as a once-daily monotherapy with clinical responses observed in an EGFRm+ population of patients with NSCLC who have previously failed on EGFR TKIs and also in patients with the T790M resistance mutation[1].
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1. Jänne PA, et al. Clinical activity of the mutant selective EGFR Inhibitor AZD9291 in patients (pts) with EGFR inhibitor resistant non-small cell lung cancer (NSCLC). Presented at the American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago, IL, USA; 30 May - 3 June 2014. Abstract available at: http://abstracts.asco.org/144/AbstView_1.... Data cited is included in final data presentation on 31 May 2014: Session: Targeting EGFR: The Next 10 Years; Clinical Science Symposium
2. National Institutes of Health. AZD9291 First Time In Patients Ascending Dose Study (AURA). Available at: http://www.clinicaltrials.gov/ct2/show/N.... Accessed April 2014.
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