Treatment of active and progressive psoriatic arthritis in adults when the response to previous disease-modifying antirheumatic drug therapy has been inadequate. Enbrel has been shown to improve physical function in patients with psoriatic arthritis, and to reduce the rate of progression of peripheral joint damage as measured by X-ray in patients with polyarticular symmetrical subtypes of the disease.
Ankylosing spondylitis
Treatment of adults with severe active ankylosing spondylitis who have had an inadequate response to conventional therapy.
Plaque psoriasis
Treatment of adults with moderate to severe plaque psoriasis who failed to respond to, or who have a contraindication to, or are intolerant to other systemic therapy including ciclosporin, methotrexate or PUVA.
Paediatric plaque psoriasis
Treatment of chronic severe plaque psoriasis in children and adolescents from the age of 8 years who are inadequately controlled by, or are intolerant to, other systemic therapies or phototherapies.
About Wyeth
Wyeth is one of the world's largest research-based pharmaceutical and health care products companies. It is a leader in the discovery, development, manufacturing, and marketing of prescription drugs and over-the-counter medications. It is also a global leader in vaccines, biotechnology and animal health care.
References:
1. Richards HL et al. The contribution of perceptions of stigmatization to disability in patients with psoriasis. J Psychosom Res. 2001;50:11-15
2. Thaci D. et al. Rapid improvement of poor quality of life with etanercept therapy in subjects with both psoriasis and psoriatic arthritis (PRESTA trial). Presented at the 18th Congress of the European Academy of Dermatology and Venereology 2009.- Abstract: A-156-0013-01005 (P116)
3. Gladman DD. et al. Psoriatic arthritis: epidemiology, clinical features, course and outcome. Ann Rheum Dis. 2005;64 (Suppl II)
4. Spondylitis Association of America. Psoriatic Arthritis (PsA) http://www.spondylitis.org/about/psoriat... (Last accessed Jan 2009)
5. Kirkham B. et al. Etanercept therapy improves enthesitis and dactylitis in subjects with psoriasis and psoriatic arthritis: The PRESTA trial. Presented at the 18th Congress of the European Academy of Dermatology and Venereology 2009. Abstract: A-156-0013-00363 / 9 October 2009
6. Enbrel EMEA SPC. http://www.emea.europa.eu/humandocs/PDFs/EPAR/Enbrel/H-262-P...
7. Wyeth data on file
For further information, please contact: Wyeth: Gill Markham, Communications - Europe, Middle East and Africa, Direct Tel: +44 (0)1628 692536, Mob: +44-(0)777-082-7753, Email: markhagl@wyeth.com. Danielle Halstrom, Communications - Global, Mobile: +1-215-280-3898, Email: halstrd@wyeth.com. OgilvyHealthPR: Mary Barrington-Ward, Tel: +44-207-108-6066, Email: mary.barrington-ward@ohpr.com
