Publicado 16/02/2018 17:01
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Entyvio® (vedolizumab) Shows Higher Rates of Mucosal Healing Versus TNFa-Antagonist Therapy in Ulcerative Colitis and Cr

Takeda Pharmaceutical Company Limited [https://www.takeda.com/investors ] is a global, research and development-driven pharmaceutical company committed to bringing better health and a brighter future to patients by translating science into life-changing medicines. Takeda focuses its R&D efforts on oncology, gastroenterology and neuroscience therapeutic areas plus vaccines. Takeda conducts R&D both internally and with partners to stay at the leading edge of innovation. Innovative products, especially in oncology and gastroenterology, as well as Takeda's presence in emerging markets, are currently fueling the growth of Takeda. Around 30,000 Takeda employees are committed to improving quality of life for patients, working with Takeda's partners in health care in more than 70 countries.

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References 

1. Faleck D, Shashi P, Meserve J, et al. Comparative effectiveness of vedolizumab and TNF-antagonist therapy in ulcerative colitis: A multicentre consortium propensity score-matched analysis. Presented at European Crohn's and Colitis Organisation (ECCO) Congress 2018, Vienna, Austria. Oral presentation #36388 (Friday, February 16, 2018, 17:00-17:10). 

2. Bohm M, Varma S, Fischer M, et al. Comparative effectiveness of vedolizumab and tumour necrosis factor-antagonist therapy in Crohn's disease: A multicentre consortium propensity score-matched analysis. Presented at European Crohn's and Colitis Organisation (ECCO) Congress 2018, Vienna, Austria. Oral presentation #36387 (Friday, February 16, 2018, 16:50-17:00). 

3. Danese S, Feagan BG, Sandborn WJ, et al. A phase 3b open-label multicentre study (VERSIFY) of the efficacy of vedolizumab on endoscopic healing in moderately to severely active Crohn's disease (CD). Presented at European Crohn's and Colitis Organisation (ECCO) Congress 2018, Vienna, Austria. Oral presentation #36350 (Friday, February 16, 2018, 16:30-16:40). 

4. Entyvio(R) Summary of Product Characteristics. September 2015. 

5. Soler D, Chapman T, Yang LL, et al. The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. J Pharmacol Exp Ther. 2009;330:864-875. 

6. Briskin M, Winsor-Hines D, Shyjan A, et al. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol. 1997;151:97-110. 

7. Eksteen B, Liaskou E, Adams DH. Lymphocyte homing and its roles in the pathogenesis of IBD. Inflamm Bowel Dis. 2008;14:1298-1312. 

8. Wyant T, Fedyk E, Abhyankar B. An overview of the mechanism of action of the monoclonal antibody vedolizumab. J Crohns Colitis. 2016;10:1437-1444. 

9. Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007;369:1627-1640. 

10. Baumgart DC, Sandborn WJ. Crohn's disease. Lancet. 2012;380:1590-1605. 

11. Torres J, Billioud V, Sachar DB, et al. Ulcerative colitis as a progressive disease: the forgotten evidence. Inflamm Bowel Dis. 2012;18:1356-1363. 

12. Ordas I, Eckmann L, Talamini M, et al. Ulcerative colitis. Lancet. 2012;380:1606-1619. 

13. Feuerstein JD, Cheifetz AS. Crohn's disease: Epidemiology, diagnosis and management. Mayo Clin Proc. 2017;92:1088-1103. 

14. Sands BE. From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology. 2004;126:1518-1532. 

15. Henckaerts L, Pierik M, Joossens M, et al. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. Gut. 2007;56:1536-1542. 

16. Kaser A, Zeissig S, Blumberg RS. Genes and environment: How will our concepts on the pathophysiology of IBD develop in the future? Dig Dis. 2010;28:395-405. 

17. Entyvio (vedolizumab) Prescribing Information. May 2014. 

CONTACT: For media outside Japan: Luke Willats, TEL: +41-44-555-1145,Luke.Willats@takeda.com; For Japanese media: Kazumi Kobayashi TEL:+81-3-3278-2095, kazumi.kobayashi@takeda.com

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